The evolution of transcriptional regulators through the recruitment of DNA-binding domains by enzymes is a widely held notion.However, few experimental approaches have directly addressed this hypothesis.Here we report the reconstruction of a plausible pathway for the evolution of an enzyme into a transcriptional regulator.The BzdR protein is the pr
We describe RosettaRemodel, a generalized framework for flexible protein design that provides a versatile and convenient interface to the Rosetta modeling suite.RosettaRemodel employs a unified interface, called a blueprint, which allows detailed control over Humidifiers many aspects of flexible backbone protein design calculations.RosettaRemodel a
BACKGROUND:Cigarette smoking is reported to decrease survival and induce chemotherapy resistance in patients with various cancers.However, the impact of cigarette smoking on patients with Pet Steps esophageal squamous cell carcinoma (ESCC) remains unknown.METHODS:A total of 1,084 ESCC patients were retrospectively enrolled from a southern Chinese i